Domar is a prescription medicine used in the treatment of indigestion, nausea, and vomiting.
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Description:
Indications of Domar Suspension
- Dyspeptic symptom complex
- Delayed stomach emptying
- Gastroesophageal reflux
- Esophagitis
- Upper abdominal pain
- The feeling of abdominal distension
- Epigastric fullness
- Early satiety
- Eructation
- Flatulence
- Vomiting and nausea
- Regurgitation of stomach contents into the mouth, with or without heartburn
- Dyspepsia without ulcers
- Acute nausea and vomiting of functional, organic, infectious, or dietetic origin
- Nausea and vomiting generated by radiotherapy or pharmacological therapy
- Nausea and vomiting induced in migraine
- Dopamine agonist-induced nausea and vomiting in Parkinson's disease
- Increasing the speed of barium transit in follow-up radiological tests
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Therapeutic Class:
- Motility Stimulants
- Motility stimulants/Dopamine antagonist
- Prokinetic drugs
Pharmacology:
- Domperidone: Dopamine agonist that blocks dopamine receptors in the ChemoreceptorTrigger Zone (CTZ) in the stomach.
- The gastroprokinetic function is based on inhibiting dopamine receptors in the gastrointestinal tract, affecting motility.
- Essentially no effect on dopaminergic receptors in the brain due to poor penetration across the blood-brain barrier.
- Restores normal upper gastrointestinal motility and tone.
- Aids stomach emptying, improves antral and duodenal peristalsis, and modulates pylorus contraction.
Dosage & Administration:
- Domperidone should be taken 15-30 minutes before meals and, if necessary, before retiring.
- Usual oral dose:
- Adults: 10-20 mg (1-2 tablets or 10-20 ml suspension), every 6-8 hours daily. Maximum dose: 80 mg daily.
- Children: 2-4 ml suspension/10 kg body weight or 0.4-0.8 ml pediatric drops/10 kg body weight, every 6-8 hours daily.
- In dyspeptic symptoms:
- Adults: 10-20 mg every 6-8 hours daily.
- Children: 0.2-0.4 mg/kg every 6-8 hours daily.
- In acute and sub-acute conditions:
- Adults: 20 mg every 6-8 hours daily.
- Children: 0.2-0.4 mg/kg every 6-8 hours daily. (Maximum treatment period: 12 weeks).
- By rectum in suppositories:
- Adults (including elderly): 30-60 mg every 4-8 hours.
- Children: Maximum daily dose rectally is 30 mg for those weighing 10 to 25 kg. The dose may be divided throughout the day if necessary.
Interaction:
- Bromocriptine's hypoprolactemic impact may be reduced by domperidone.
- Antimuscarinics and opioid analgesics may counteract Domperidone's effect on GI function.
- Caution is advised when used with MAO (monoamine oxidase) inhibitors.
Contraindications:
- Known hypersensitivity to domperidone.
- Neonates.
- Gastrointestinal stimulation potentially harmful conditions: gastrointestinal hemorrhage, mechanical obstruction, or perforation.
- Patients with a prolactin-releasing pituitary tumor (prolactinoma).
Side Effects:
- Hyperprolactinemia (1.3%)
- Galactorrhea, breast enlargement, soreness, reduced libido.
- Common: Dry mouth, thirst, headache, nervousness, drowsiness, diarrhea, skin rash, itching.
- Extra-pyramidal reactions were seen in 0.05% of patients in clinical studies.
Pregnancy & Lactation:
- Not recommended during pregnancy; safety not established.
- Can help with galactorrhea and postpartum lactation.
- Secreted in breast milk in small amounts, considered not dangerous.
Precautions & Warnings:
- Caution in children due to the risk of extrapyramidal effects.
- Caution in patients with hepatic impairment due to high metabolism in the liver.
Storage Conditions:
- Store at or below 30°C, away from light and moisture.
- Keep out of reach of youngsters.
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information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
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